The Horizan Peninsula is well known for its use of grafts for both enhancement as well as disability assistance. Develyn Barbie and Karvi Massiri being the well known examples of graft users to replace their missing arm.
Cragmoore is home to a large variety of metal implements on the other hand, best well shown by Ashur Holdok and most of his limbs being mechanical.
Magical prosthetics also exist, often to be manufactured in Mogxa and Vilhun from which they are exported.
Of course, any and all of the above can craft the other types of prosthetics, but these are the regional centers of each type.
Known wheelchairs users include Councilman Redd.